- Original Article
- Outcomes of chronic dialysis in Korean children with respect to survival rates and causes of death
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Hye Jin Chang, Kyoung Hee Han, Min Hyun Cho, Young Seo Park, Hee Gyung Kang, Hae Il Cheong, Il Soo Ha
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Clin Exp Pediatr. 2014;57(3):135-139. Published online March 31, 2014
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Purpose Adult Korean patients on chronic dialysis have a 9-year survival rate of 50%, with cardiovascular problems being the most significant cause of death. The 2011 annual report of the North American Pediatric Renal Trials and Collaborative Studies group reported 3-year survival rates of 93.4% and relatively poorer survival in younger patients. MethodsIn this study, we have reviewed data from Korean Pediatric... |
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- Case Report
- Shiga toxin-associated hemolytic uremic syndrome complicated by intestinal perforation in a child with typical hemolytic uremic syndrome
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Hye Jin Chang, Hwa Young Kim, Jae Hong Choi, Hyun Jin Choi, Jae Sung Ko, Il Soo Ha, Hae Il Cheong, Yong Choi, Hee Gyung Kang
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Clin Exp Pediatr. 2014;57(2):96-99. Published online February 24, 2014
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Hemolytic uremic syndrome (HUS) is one of the most common causes of acute renal failure in childhood and is primarily diagnosed in up to 4.5% of children who undergo chronic renal replacement therapy. Escherichia coli serotype O157:H7 is the predominant bacterial strain identified in patients with HUS; more than 100 types of Shiga toxin-producing enterohemorrhagic E. coli (EHEC) subtypes have... |
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- A case of pseudohypoaldosteronism type 1 with a mutation in the mineralocorticoid receptor gene
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Se Eun Lee, Yun Hye Jung, Kyoung Hee Han, Hyun Kyung Lee, Hee Gyung Kang, Il Soo Ha, Yong Choi, Hae Il Cheong
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Clin Exp Pediatr. 2011;54(2):90-93. Published online February 28, 2011
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Pseudohypoaldosteronism type 1 (PHA1) is a rare form of mineralocorticoid resistance characterized in newborns by salt wasting with dehydration, hyperkalemia and failure to thrive. This disease is heterogeneous in etiology and includes autosomal dominant PHA1 owing to mutations of the NR3C2 gene encoding the mineralocorticoid receptor, autosomal recessive PHA1 due to mutations of the epithelial sodium channel (ENaC) gene, and... |
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- Original Article
- Validation study of the Dinamap ProCare 200 upper arm blood pressure monitor in children and adolescents
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Chong Guk Lee, Hyang Mi Park, Hye Jung Shin, Jin Soo Moon, Yeong Mi Hong, Nam Soo Kim, Il Soo Ha, Myeong Jin Chang, Kyeong Won Oh
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Clin Exp Pediatr. 2011;54(11):463-469. Published online November 30, 2011
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Purpose To validate the Dinamap ProCare 200 blood pressure (BP) monitor against a mercury sphygmomanometer in children 7 to 18 years old in accordance with the 2010 International Protocol of European Society of Hypertension (ESH-IP2) and the British Hypertension Society (BHS) protocol. MethodsForty-five children were recruited for the study. A validation procedure was performed following the protocol based on the ESH-IP2 and... |
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- Case Report
- Renal transplantation in a patient with Bartter syndrome and glomerulosclerosis
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Se Eun Lee, Kyoung Hee Han, Yun Hye Jung, Hyun Kyung Lee, Hee Gyung Kang, Kyung Chul Moon, Il Soo Ha, Yong Choi, Hae Il Cheong
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Clin Exp Pediatr. 2011;54(1):36-39. Published online January 31, 2011
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Bartter syndrome (BS) is a clinically and genetically heterogeneous inherited renal tube disorder characterized by renal salt wasting, hypokalemic metabolic alkalosis and normotensive hyperreninemic hyperaldosteronism. There have been several case reports of BS complicated by focal segmental glomerulosclerosis (FSGS). Here, we have reported the case of a BS patient who developed FSGS and subsequent end-stage renal disease (ESRD) and provided... |
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- A case of Bartter syndrome type I with atypical presentations
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Eun Hye Lee, Ju Sun Heo, Hyun Kyung Lee, Kyung Hee Han, Hee Gyung Kang, Il Soo Ha, Yong Choi, Hae Il Cheong
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Clin Exp Pediatr. 2010;53(8):809-813. Published online August 31, 2010
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Bartter syndrome (BS) is an autosomal recessively inherited rare renal tubular disorder characterized by hypokalemic metabolic alkalosis and hyperreninemic hyperaldosteronism with normal to low blood pressure due to a renal loss of sodium. Genetically, BS is classified into 5 subtypes according to the underlying genetic defects, and BS is clinically categorized into antenatal BS and classical BS according to onset... |
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- Original Article
- Effect of renin inhibition on an experimental glomerulonephritis - a preliminary report
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Ju Hyung Kang, Jae Kyung Huh, Young Sook Lee, Ji Young Han, Il Soo Ha
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Clin Exp Pediatr. 2009;52(8):938-943. Published online August 15, 2009
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Purpose:We performed this study in order to investigate the effect of direct renin inhibition on an experimental animal model
with nephrotoxic serum nephritis and tried to give useful information for clinical research and renin inhibitor treatment.
Methods:Thirty BALB/c 6-week-old male mice were divided into 4 groups: control group (CO, n=5), control-treatment group
with aliskiren (CT, n=5), disease group (DO, n=10), and disease treatment... |
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- Polymorphisms of the NR3C1 gene in Korean children with nephrotic syndrome
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Hee Yeon Cho, Hyun Jin Choi, So Hee Lee, Hyun Kyung Lee, Hee Kyung Kang, Il Soo Ha, Yong Choi, Hae Il Cheong
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Clin Exp Pediatr. 2009;52(11):1260-1266. Published online November 15, 2009
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Purpose : Idiopathic nephrotic syndrome (NS) can be clinically classified as steroid-sensitive and steroid-resistant. The detailed mechanism of glucocorticoid action in NS is currently unknown.
Methods : In this study, we investigated 3 known single nucleotide polymorphisms (SNPs) (ER22/23EK, N363S, and BclI) of the glucocorticoid receptor gene (the NR3C1 gene) in 190 children with NS using polymerase chain reaction-restriction fragment... |
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- Review Article
- Peritoneal dialysis in children and adolescents
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Il Soo Ha
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Clin Exp Pediatr. 2009;52(10):1069-1074. Published online October 15, 2009
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Peritoneal dialysis is a preferred modality of replacement therapy in children and adolescents with end-stage renal disease waiting for kidney transplantation. Recent development of pediatric swan-neck catheters with cuffs, novel dialysis solutions, and cyclers for automated peritoneal dialysis enabled more flexible prescriptions of dialysis with less complication, and improved patients' activities as well as the dialysis adequacy. Principles and practical... |
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- Original Article
- Risk Factors of Urinary Tract Infections Due to Extended-spectrum β-lactamase Producing Escherichia coli in Children
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Nam Hee Kim, Jin A Lee, Yun Kyung Kim, Eun Hwa Choi, Il Soo Ha, Hoan Jong Lee, Yong Choi
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Clin Exp Pediatr. 2004;47(2):164-169. Published online February 15, 2004
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Purpose : This study was performed to identify risk factors for urinary tract infection(UTI) by extended-spectrum β-lactamase(ESBL)-producing Escherichia coli in children.
Methods : We analyzed 125 episodes of UTI which were developed in 112 children at the Seoul National University Children's Hospital from July to December 2002. Medical records of 74 episodes of UTI caused by E. coli were reviewed in... |
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- Urinary Tract Infections in Febrile Infants under Three Months of Age
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Byung Wook Eun, Yoo Mi Chung, Hee Gyung Kang, Il Soo Ha, Hae Il Cheong, Hoan Jong Lee, Yong Choi
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Clin Exp Pediatr. 2003;46(3):265-270. Published online March 15, 2003
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Purpose : To characterize the infants under 3 months of age with urinary tract infections(UTIs), and especially patients with bacteremia or meningitis
Methods : Hospital records of all the infants under 3 months of age discharged from our hospital for 69 consecutive months with the diagnosis of initial episode of UTI were reviewed. UTI was defined when patients had fever with... |
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- Case Report
- A Case of Systemic Capillary Leak Syndrome in a Child
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Taeg Young Lee, Yoo Mi Chung, Hee Gyung Kang, Il Soo Ha, Hae Il Cheong, Yong Choi
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Clin Exp Pediatr. 2002;45(10):1292-1297. Published online October 15, 2002
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Systemic capillary leak syndrome(SCLS) is a rare disorder of unknown etiology, which is characterized
by recurrent attacks of hypotension, hemoconcentration, and hypoalbuminemia. Urinary or
enteric loss of protein is not demonstrated. It is often associated with monoclonal gammopathy,
but does not manifest multiple myeloma. Since Clarkson et al. described the first case in a 34-
year-old woman, about 50 cases have been reported in... |
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- A Case of Hereditary Fructose Intolerance
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Eun Kyeong Kang, Hye Ran Yang, Jeong Kee Seo, Sun Hoan Bai, Joo Young Jeong, Jae Sung Ko, Il Soo Ha, Jeong Han Song, Kyeong Ae Wi, Yoon Sook Shin
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Clin Exp Pediatr. 2002;45(1):120-124. Published online January 15, 2002
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Hereditary fructose intolerance(HFI) is an autosomal recessive disease caused by catalytic deficiency
of aldolase B in which affected homozygotes develop hypoglycemia and abdominal symptoms
after taking foods containing fructose. Chronic exposure to fructose may lead to progressive
hepatic injury, renal injury, growth retardation, and ultimately to liver and kidney failure. Herein,
we report a case of HFI with presentation of episodic vomiting, diarrhea, cold... |
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- Three Cases of Urine Abnormalities Associated with Ketogenic Diet
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Hye Won Hahn, Ki Jung Kim, Il Soo Ha, Hae Il Jung, Yong Seung Hwang, Yong Choi
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Clin Exp Pediatr. 2001;44(6):709-713. Published online June 15, 2001
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Ketogenic diet is a high-fat, low carbohydrate, low protein diet used in treatment of pediatric epilepsy since the 1920s. Currently it is used primarily to treat refractory childhood epilepsy. Few serious complications caused by ketogenic diet have been reported. Short-term complications include dehydration, hypoglycemia, vomiting, diarrhea, and refusal to eat. Long-term complications include kidney stones, recurrent infections, metabolic derangement, hypercholesterolemia,... |
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- Original Article
- Factors Associated with Renal Failure in Children with Primary Vesicoureteral Reflux
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Kyung Mi Park, Kyung Hoon Paek, Jae Hong Min, Jung Su Kim, Il Soo Ha, Kwang Myung Kim, Hae Il Cheong, Hwang Choi, Yong Choi
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Clin Exp Pediatr. 1999;42(7):959-965. Published online July 15, 1999
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Purpose : The pathophysiologic mechanisms and risk factors of renal functional deterioration are still controversial. We analyzed the factors associated with renal failure in children with primary vesicoureteral reflux.
Methods : The medical records of 166 children who were diagnosed with primary vesicoureteral reflux from Jan. 1985 to Dec. 1996 in the Department of Pediatrics, Seoul National University Children's Hospital... |
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- Renal Problems in Wilson Disease
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Il Soo Ha, Jun Ho Lee, Yeon Ho Choe, Hae Il Cheong, Sei Won Yang, Young Yull Koh, Jeong Kee Seo, Yong Choi
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Clin Exp Pediatr. 1999;42(6):817-824. Published online June 15, 1999
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Purpose : Wilson disease is a hereditary metabolic disorder characterized by an accumulation of copper in tissues which sometimes results in renal problems. This study was performed to evaluate the prevalences of the renal problems in Wilson disease and related risk factors.
Methods : In 31 patients with Wilson disease, we looked for renal problems by history taking, physical examination... |
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- A Case of Successful Treatment of Pulmonary Alveolar Hemorrhage with Plasmapheresis in Child with Systemic Lupus Erythematosus
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Jae Hong Min, Kyung Hoon Paek, Kyung Mi Park, Jin Soon Hwang, Jung Sue Kim, Il Soo Ha, Hae Il Cheong, Kyou Seup Han, Yong Choi
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Clin Exp Pediatr. 1998;41(7):974-978. Published online July 15, 1998
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Seoul National University College of Medicine, Seoul, Korea
Pulmonary hemorrhage is a rare but possibly fatal complication of systemic lupus erythematosus(SLE). We report a case of massive pulmonary hemorrhage in a 14-year-old boy recently diagnosed as SLE. He developed massive pulmonary hemorrhage during the courses of i.v. methylprednisolone pulse therapy, and did not respond to i.v. cyclophosphamide. However, he rapidly... |
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- Longterm Follow-up of Autosomal Recessive Polycystic Kidney Disease
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June Huh, Il Soo Ha, Hae Il Cheong, Jeong Kee Seo, Yong Choi
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Clin Exp Pediatr. 1998;41(12):1693-1699. Published online December 15, 1998
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Purpose : This study was aimed to assess the clinical manifestations and courses of autosomal recessive polycystic kidney disease(ARPKD).
Methods : The medical records of 10 children diagnosed as infantile or juvenile ARPKD at Seoul National University Children's Hospital between January, 1984 and December, 1996, were reviewed, retrospectively.
Results : The average age at diagnosis was 3 8/12 years(4months-7 3/12 years)... |
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- Case Report
- Three Cases of Cardiac Arrythmias Associated with Intravenous Methylprednisolone Pulse Therapy
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Jun Ho Lee, Jun Huh, Myung Dong Shin, Dong Kyu Jin, Il Soo Ha, Hae Il Cheong, Chung Il Noh, Yong Choi
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Clin Exp Pediatr. 1997;40(3):393-407. Published online March 15, 1997
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Methylprednisolone(MP) is administered by means of intravenous pulse therapy especially in the patients with focal segmental glomerulosclerosis(FSGS). There have been reports of its complications in a few increasing frequency. We experienced three cases of cardiaccomplications during intravenous pulsetherapy.Therewere onecaseof2¡ÆA-V block(Mobitztype I) and two cases of bradycardia and hypotension. In the former,2¡ÆA-V block in the first case deveoloped 45 hours after... |
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- Primary Distal Renal Tubular Acidosis in Children
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Byoung Chul Kang, Hye Won Park, Il Soo Ha, Hae Il Cheong, Yong Choi
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Clin Exp Pediatr. 1996;39(7):987-996. Published online July 15, 1996
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Purpose : This study was designed to examine the clinical characteristics and the effect of
treatment in children with primary distal renal tubular acidosis (dRTA).
Methods : Medical records of 4 children diagnosed as dRTA at Seoul National University
Children's Hospital were reviewed, and the clinical manifestations, laboratory findings, diagnostic
criteria and effects of treatments were investigated.
Results : All cases presented with growth retardation.... |
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- Case Report
- A Case of Mauriac's syndrome
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Se Young Kim, Choong Ho Shin, Il Soo Ha, Hae Il Cheong, Sei Won Yang, Yong Choi, Hyung Ro Moon
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Clin Exp Pediatr. 1996;39(7):1020-1024. Published online July 15, 1996
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Mauriac's syndrome was described in the 1920s, as a triad of poorly controlled insulin
dependent diabetes mellitus, profound growth retardation, and hepatomgaly. Following the wide
availability of insulin and intensification of diabetic control, this entity has become quite rare. A
9-year-old female child was transferred to pediatric OPD of SNUCH because of hyperglycemia,
short stature, and visual disturbance. Five years prior to admission, she... |
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- Antiphospholipid Syndrome Presented with Pulmonary Embolism and Deep Venous Thrombosis in Child
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Ran Lee, Il Soo Ha, Hae Il Cheong, Yong Choi
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Clin Exp Pediatr. 1996;39(5):722-726. Published online May 15, 1996
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Antiphospholipid syndrome is a thrombotic disorder and the serologic marker of the
syndrome is antiphospholipid antibody(lupus anticoagulant, anticardiolpin antibody, or both). In a 13-year-old girl who presented with dyspnea, pulmonary embolism and
femoral vein thrombosis were demonstrated by lung scan and abdominal ultrasonography.
She had 3 out of 11 criteria for the diagnosis of SLE, such as thrombocytopenia, positive antinuclear antibody, low C3... |
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- Isolated Splenic Infarction in a Girl with Systemic Lupus Erythematosus
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Kyung Ran Park, Hee Eun Lee, Yun Ae Jeon, Il Soo Ha, Hae Il Cheong, Joong Gon Kim, Yong Choi
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Clin Exp Pediatr. 1996;39(4):562-566. Published online April 15, 1996
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Splenic infarction is a rare disease and usually detected as a complication of SBE, atrial fibrillation, hemoglobinopathy, or myeloproliperative disorders. Although thrombotic event, such as deep vein, cerebral or renal thrombosis, is a frequent complication of SLE, there have been only a couple of cases documenting splenic infarction complicated in SLE. This is, to our knowledge, the first case report... |
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- Original Article
- Clinicopathological Study about Childhood Primary Nephrotic Syndrome Resistant to 4-week Daily Steroid Therapy
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Jung Sue Kim, Il Soo Ha, Hae Il Cheong, Yong Choi
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Clin Exp Pediatr. 1996;39(12):1729-1735. Published online December 15, 1996
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Purpose : Steroid-resistant nephrotic syndrome in children is difficult to manage and tends to
progress to chronic renal failure. We studied clinicopathological correlations in primary nephrotic
syndrome in children resistant to 4-week daily steroid therapy.
Methods : Among children who had been admitted to Seoul National University Children's
Hospital during the period between Oct. 1985 and Jul. 1995 and diagnosed as primary nephrotic
syndrome, 87... |
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- Case Report
- A Case of Neonatal Cholestasis with Arthrogryposis Multiplex Congenita and Renal Tubular Insufficiency(ARC Syndrome)
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Hi Soo Rhee, Soon Young Kim, Nam Sun Baik, Il Soo Ha, Jeong Kee Seo
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Clin Exp Pediatr. 1996;39(1):126-130. Published online January 15, 1996
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We report a case of ARC syndrome with arthrogryposis multiplex congenita, renal tubular insufficiency and cholestasis. The Patient presented in the early neonatal period with micrognathia, low set ears, high arched palate, multiple joint contracture, conjugated hyperbilirubinemia and failure to thrive. He died at the age of 1 month despite medical therapy. Findings of renal tubular insufficiency included persistent renal... |
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- Original Article
- Acute Hemorrhagic Cystitis(AHC) in Children -Etiology and Clinical Characteristics-
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Jin Won Pyo, Eun Hwa Choi, Jin Young Park, Hoan Jong Lee, Hae Il Cheong, Il Soo Ha, Yong Choi, Kwang Myung Kim, Hwang Choi, Je Geun Chi
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Clin Exp Pediatr. 1995;38(2):207-215. Published online February 15, 1995
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Purpose : AHC characterized by sudden onset of gross hematuria, dysuria and frequency oc curs in children and young adults as a self-limited disease that should be differentiated from se rious renal disorders. We have performed this study to establish the cause and characterize the clinical features of this illness in Korean children.
Methods : 19 cases collected prospectively for 30... |
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- Case Report
- Recurrent Hematuria due to Renal Hypouricemia
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Kyu Young Kim, Il Soo Ha, Hae Il Cheong, Yong Choi
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Clin Exp Pediatr. 1995;38(1):129-132. Published online January 15, 1995
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A marked low concentration of serum uric acid(0.7-1.2mg/dl) was detected in a 14-year-old boy with recurrent episodes of gross hematuria. The hypouricemia accompanied with a markedly increased urinary clearance of uric acid (32.6-56.0ml/min), which was only minimally changed after both the administration of pyrazinamide, and inhibitor of the renal tubular secretion of uric acid, and the administration of probenecid, and... |
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- Original Article
- Pheochromocytoma in Children
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Tae Sue Ha, Jae Hong Park, Il Soo Ha, Hae Il Cheong, Yong Choi, Hyung Ro Moon, Gui Won Park
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Clin Exp Pediatr. 1994;37(7):961-968. Published online July 15, 1994
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We Reviewed 10 hypertensive children with pheochromocytoma retrospectively and the following results were obtained.
1) Out of 10 patients, 7 were male and 3 female. Age ranged from 5.5 years to 13.8 years and their median age was 9.9 years.
2) They complained of sweating, lethargy, headache, or chest pain and so on, Hypertension were noticed in all patients. Heart murmurs were... |
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- A Clinical Observation on Lupus Nephritis in Children
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Kang Mo Ahn, Jae Sung Ko, Hye Won Park, Il Soo Ha, Hae Il Cheong, Yong Choi, Hee Joo Kim
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Clin Exp Pediatr. 1994;37(6):842-849. Published online June 15, 1994
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We reviewed the clinical features, histrologic patterns and clinical courses of 30 children with lupus nephritis retrospectively, and the results were summerized as follows;
1) The male to female ratio was 1:2.8, and the mean age at the onset was 108/12 years.
2) The clinical symptoms were diverse, and malaise, weight loss, anorexia, fever and malar rash were the most frequent findings.
3)... |
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- Hypophosphatemic Rickets
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Jae un, June Huh, Il Soo Ha, Hae Il Cheong, Yong Choi
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Clin Exp Pediatr. 1994;37(3):376-382. Published online March 15, 1994
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The clinical data of 27 patients with hypophosphatemic rickets treated with phosphate and 1 α-hydroxyvitamin D were analysed retrospectively. The median age at diagnosis was 4 years, and the main clinical manifestations were bowleg and short stature. Among total 24 families, 5 families(21%) had X-linked dominant mode of inheritance, 1 family (4%) had autosomal dominant mode and 17 families (71%)... |
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- Serum Alkaline Phosphatase Activity after Intravenous Administration of Albumin Preparation
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June Huh, Kang Mo Ahn, Ja Wook Koo, Il Soo Ha, Hae Il Cheong, Yong Choi
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Clin Exp Pediatr. 1993;36(6):830-836. Published online June 15, 1993
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Serum alkaline phosphatase(AP) activity is elevated in hepatobiliary disease, bone disease, pregnancy and certain neoplasms. Recently we experienced marked elevation of serum AP activity after administration of ablumin preparation in nephrotic patients who suffered from hypovolemic symptoms. So serum AP activity and the isoenzymes in the albumin preparations & patient뭩 serum after the administration of albumin preparation were studied. Serum... |
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- Nephrotic Syndrome under 2 Years of Age
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Jae Sung Ko, Kang Mo Ahn, Hye Won Park, Il Soo Ha, Hae Il Cheong, Yong Choi, Kwang Wook Ko
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Clin Exp Pediatr. 1993;36(10):1395-1401. Published online October 15, 1993
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There had been total 20 patients with early onset (4 months~2 years) primary nephrotic syndrome in the Deparment of Pediatrics, Seoul National University Children's Hospital, during the period from March 1987 to February 1993. We analysed clinical courses, response to treatment, pathological findings and prognosis of the patients And the results were as follows;
1) The initial responders to steroid treatment... |
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- Acute Renal Failure Following Cardiac Surgery
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Kang Yong Park, Yeon Ho Choi, Tae Sun Ha, Il Soo Ha, Hae Il Cheong, Yong Choi, Kwang Wook Ko, Joon Ryang Rho
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Clin Exp Pediatr. 1992;35(9):1198-1209. Published online September 15, 1992
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A retrospective study of 452 patients who undertook cardiac surgery was performed to determine the pevalence, etiology, and clinical features of postoperative acute renal failure(ARF). The overall incidence of ARF following cardiac surgery was 4.65%(21/452). The incidence of ARF following open heart surgery(OHS) was 5.11%, and that following closed heart surgery was 2.50%. Preoperactive risk factors noted in the development... |
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- Acquired Renal Cystic Disease in Childhood Chronic Renal Failure
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Tae Sun Ha, Seong Hoon Ha, Il Soo Ha, Hae Il Cheong, Yong Choi, Kwang Wook Ko, Woo Sun Kim, Kim In One
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Clin Exp Pediatr. 1992;35(8):1044-1050. Published online August 15, 1992
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The authors evaluated 19 childrenwith chronic renal failure patients diagnosed and followed up at the Department of Pediatrics, Seoul National University Hospital for the detection of acquired renal cystic disease (ARCD) with two radiologists by the means of ultrasonography.
The results were as follows:
1) Of the 19 patients, male to femals ratio was 14:5 and of them, hemodialysis and peritoneal dialysis... |
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- A Clinical Aspect of the Hemolytic Uremic Syndrome
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Hye Won Park, Tae Sun Ha, Il Soo Ha, Hae Il Cheong, Yong Choi, Kwang Wook Ko
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Clin Exp Pediatr. 1992;35(7):909-920. Published online July 15, 1992
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We reviewed the medical records of 14 children (8 girls, 6 boys), diagnosed as hemolytic uremic syndrome at Seoul National University Children뭩 Hospital from 1981 to 1990. The age at presentation ranged from 1 month to 10 years, with a mean age of 2.7 years. Only eight (57.1%) of the children had diarrheal prodrome and five (35.7%) had grossly bloody... |
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- Weight and morphologic development of prenatal human thymus.
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Il Soo Ha, Kwang Wook Ko, Je Geun Chi
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Clin Exp Pediatr. 1991;34(8):1057-1069. Published online August 31, 1991
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Thymus is a primary lymphoid organ which has an important role in maturation of immune
competence. This organ matures earlier than the other organs, and the informations about its
prenatal development are essential to understand the maturation of human immunity. To delineate
the weight and morphologic development of prenatal thymus, the authors measured the weight of 221,
and observed gross and histologic features of... |
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- A comparison between remission and nonremission groups of hepatitis B virus-associated membranous nephropathy in children.
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Kang Yong Park, Hye Won Park, Yon Ho Choe, Tae Sun Ha, Il Soo Ha, Yong Choi, Kwang Wook Ko, Hyun Soon Lee, Yong Il Kim
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Clin Exp Pediatr. 1991;34(11):1512-1518. Published online November 30, 1991
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We analyzed medical records of 35 patients with Hepatitis B virus-associated Membranous
Nephropathy proven by kidney biopsy at SNUCH from Jan. 1975 to Jun. 1990. Clinical presentation,
laboratory and pathologic findings were compared between remission group (who are free of
proteinuria and edema in current status) and nonremission group (who have either proteinuria or
edema).
Age at onset was younger in remission group (4.51 ±2.93... |
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- A case of Second Malignant Neoplasm Complicating Hodgkin's Disease in Remission.
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Hong Hoe Koo, Jong Woon Choi, Sang Oh Na, Il Soo Ha, Hee Young Shin, Hyo Seop Ahn, Yeon Lim Suh, Chul Woo Kim, Je Geun Chi
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Clin Exp Pediatr. 1990;33(4):564-572. Published online April 30, 1990
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Recent advances in the treatment of cancer have resulted in increased survival and possible cure for
many malignant disorders, particularly childhood cancers. There has been a marked improvement in
the treatment of childhood Hodgkin’s disease, and five-year survival rates for even advanced stages
of Hodgkin’s disease approach or exceed more than 75% with modern treatment policies. However,
successful therapy in childhood cancer is frequently... |
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- A case of congenital dyserythropoietic Anemia.
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Sang Oh Na, Seong Hoon Ha, Hong Hoe Koo, Hee Young Shin, Il Soo Ha, Hyo Seop Ahn, Doek Ja Oh, Myoung Hee Park
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Clin Exp Pediatr. 1990;33(3):410-415. Published online March 31, 1990
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The congenital dyserythropoietic anemia refers to a group of hereditary disorders of erythropoiesis
characterized by ineffective erythropoiesis, multinuclearity of erythroblasts, and secondary hemo-
chromatosis. The authors report a case of anemia in a 4 month-old girl whose bone marrow showed
dyserythropoietic features. A brief review of referential literatures was made. |
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- Cyclophosphamide-Induced Hemorrhagic Cystitis in Acute Lymphocytic Leukemia and Non-Hodgkin Lymphoma.
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Young Seo Park, Il Soo Ha, Soon Ki Kim, Hae Il Jung, Yong Choi, Hyo Seop Ahn
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Clin Exp Pediatr. 1989;32(5):665-669. Published online May 31, 1989
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We studied the cyclophosphamide-induced hemorrhagic cystitis in 72 cases of acute lymphocytic
leukemia or Non-Hodgkin lymphoma, which had been treated at Seoul National University Children'
s Hospital from June, 1985 to May, 1988
1) Among 72 cases treated with cyclophosphamide, 6 cases(12.8%) developed hemorrhagic cystitis
in 47 cases of acute lymphocytic leukemia and 2 cases(8.0%) in 25 cases of Non-Hodgkin lymphoma.
2) The development of... |
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- Infections in Childhood Leukemia.
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Choong Won Lee, Young Sik Kim, Byung Kyu Park, Soon Ki Kim, Il Soo Ha, Hoan Jong Lee, Hyo Seop Ahn
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Clin Exp Pediatr. 1989;32(5):659-664. Published online May 31, 1989
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A retrospective study was performed on twenty-nine children, who had experienced infection one
or more times, among the thirty-eight children diagnosed as leukemia at the Department of
Pediatrics, Seoul National University Hospital, between January, 1984 and June, 1985, and followed
up for more than three years.
The results were as follows;
1) The age of patients ranged from I year 5 months to 14 years... |
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- Three Cases of Typhlitis during Treatment for Acute Myelocytic Leukemia in Children.
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Soon Mee Park, Il Soo Ha, Hoan Jong Lee, Jeong Kee Seo, Hyo Seop Ahn, Kyung Mo Yeon
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Clin Exp Pediatr. 1989;32(10):1455-1462. Published online October 31, 1989
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Typhlitis is a rare necrotizing colitis in which inflammation is confined to cecum. It occurs during
chemotherapy for malignancies, in terminal stage of aplastic anemia, in transplant patients. The
pathogenesis of typhlitis has included leukemic infiltration of the bowel, thrombocytopenia, direct
toxic effects of chemotherapy, steroid, bacterial invasion of the bowel wall secondary to neutropenia
and alteration of the bowel flora by broad-spectrum antibiotics.... |
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- Angiolymphoid Hyperplasia with Eosinophilial: Kiruma's disease.
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Choong Won Lee, Young Sik Kim, Soon Ki Kim, Il Soo Ha, Hyo Seop Ahn, Je Geun Chi, Il Han Kim
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Clin Exp Pediatr. 1989;32(10):1416-1421. Published online October 31, 1989
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Kimura’s disease is a rare, benign disease characterized by single or multiple subcutaneous nodules,
eosinophilia and distinctive histopathologic features. Seven cases of Kimura’s disease under 15 yeaps
of age who were admitted to the Dept, of Pediatrics, Seoul National University Hospital from Apr.
1983 to July 1987 were reviewed.
The results were as follows:
1) The lesions were noted between the ages of 28 months and... |
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- A Clinical Observation on the Incidence of Childhood Leukemia.
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Hyo Seop Ahn, Il Soo Ha, Soon Ki Kim, Hoan Jong Lee, Chang Yee Hong
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Clin Exp Pediatr. 1988;31(7):841-849. Published online July 31, 1988
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We have analysed the type, age, sex, initial hematologic values and cell markers in 295 children,
who had been diagnosed as leukemia at the department of pediatrics, Seoul National University
Hospital, from Jan. 1983 to Dec. 1987.
The patients were composed of 197 cases (66.8%) of ALL, 82 cases (27.7%) of ANLL and 16 cases
(5.5%) of CML. FAB subclassification have been done in... |
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- Acute Tumor Lysis Syndrome in Burkitt Lymphoma.
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Dong Kyu Jin, Soo Jong Hong, Il Soo Ha, Hyo Seop Ahn, Yong Choi, Chang Yee Hong
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Clin Exp Pediatr. 1988;31(3):362-369. Published online March 31, 1988
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To assess the tumor lysis syndrome in Burkitt lymphoma, we analyzed the clinical and laboratory
findings of 17 patients with Burkitt lymphoma who were admitted to the Department of Pediatrics,
Seoul National University Hospital from January 1979 to December 1986.
The acute tumor lysis syndrome was diagnosed when two of the five following metabolic abnormal-
ities were met:
① hyperuricemia (≥8.0mg/dl), ② hyperphosphatemia (≥5.5 mg/dl),... |
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- High-Dose Cytosine Arabinoside (HD Ara-C) Therapy for Refractory Acute Leukemia in Children.
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Il Soo Ha, Hyo Seop Ahn, Chang Yee Hong
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Clin Exp Pediatr. 1988;31(10):1328-1337. Published online October 31, 1988
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Eleven children with refractory acute leukemia were treated with high dose cytosine arabinoside
(HD Ara-C), given at a dosage of 3 gm/m2 intravenously over about one hour every 12 hours for four
to eight doses. The antileukemic effects were evaluable in nine of the patients, two with ALL, seven
with ANLL. Six of the seven patients with ANLL attained complete remission, while neither... |
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- A Retrospective Study on the Effect of Cyclophosphamide in Children with Minmal Change Nephrotic Syndrome.
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Il Soo Ha, Kwang Wook Ko, Yong Il Kim
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Clin Exp Pediatr. 1987;30(2):158-174. Published online February 28, 1987
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Thirty one children associated with biopsy-proven minimal change nephrotic syndrome with
frequent relapse, were placed on cyclophosphamide, and its effect was analyzed.
Cyclophosphamide was given with the dosage of 2.46±0.42 mg/kg/day for 58±7 days along with
the alternate day corticosteroid. Sixty three percent of the patients showed complete remission and
twenty seven percent of the patients resulted in partial remission after the treatment. Those... |
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